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https://dora.health.qld.gov.au/qldresearchjspui/handle/1/10768| Title: | Infection by Clonally Related Mycobacterium abscessus Isolates: The Role of Drinking Water | Authors: | Thomson, Rachel M Wheeler, Nicole Stockwell, Rebecca E Bryant, Josephine Taylor, Steven L Leong, Lex E X Le, Trieu Rogers, Geraint B Carter, Robyn Sherrard, Laura J Powell, Harry Simpson , Graham Patterson-Fahy, Kirby Wainwright, Claire E Floto, R Andres Parkhill, Julian Bell, Scott C |
Issue Date: | 2025 | Publisher: | American Thoracic Society | Source: | Thomson RM, Wheeler N, Stockwell RE, Bryant J, Taylor SL, Leong LEX, Le T, Rogers GB, Carter R, Sherrard LJ, Powell H, Simpson G, Patterson-Fahy K, Wainwright CE, Floto RA, Parkhill J, Bell SC. Infection by Clonally Related Mycobacterium abscessus Isolates: The Role of Drinking Water. Am J Respir Crit Care Med. 2025 May;211(5):842-853. doi: 10.1164/rccm.202409-1824OC. PMID: 40072241; PMCID: PMC12091025. | Journal Title: | American journal of respiratory and critical care medicine | Journal: | American Journal of Respiratory and Critical Care Medicine | Abstract: | Rationale: Mycobacterium abscessus (MABS) group bacteria cause lethal infections in people with chronic lung diseases. Transmission mechanisms remain poorly understood; the detection of dominant circulating clones (DCCs) has suggested the potential for person-to-person transmission. Objectives: This study aimed to determine the role of drinking water in the transmission of MABS. Methods: A total of 289 isolates were cultured from respiratory samples (n = 231) and drinking water sources (n = 58) across Queensland, Australia. Measurements and Main Results: Whole-genome sequences were analyzed to identify DCCs and determine relatedness. Half of the isolates (n = 144; 49.8%) clustered with previously described DCCs, of which 30 formed a clade within DCC5. Pan-genomic analysis of the water-associated DCC5 clade revealed an enrichment of genes associated with copper resistance. Four instances of plausible epidemiological links were identified between genomically related clinical and water isolates. Conclusions: We provide evidence that drinking water is a reservoir for MABS and may be a vector in the chain of MABS infection. | Description: | Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated author: Graham Simpson | DOI: | 10.1164/rccm.202409-1824OC | Keywords: | Mycobacterium abscessus;drinking water;environmental transmission;cystic fibrosis;bronchiectasis | Type: | Article |
| Appears in Sites: | Cairns & Hinterland HHS Publications Queensland Health Publications |
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