Please use this identifier to cite or link to this item:
https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5248
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, Gang | en |
dc.contributor.author | Baird, Alan W | en |
dc.contributor.author | Parsons, Marie J | en |
dc.contributor.author | Fan, Kening | en |
dc.contributor.author | Skerrett-Byrne, David A | en |
dc.contributor.author | Nair, Prema M | en |
dc.contributor.author | Makanyengo, Samwel | en |
dc.contributor.author | Chen, Jinbiao | en |
dc.contributor.author | Neal, Rachel | en |
dc.contributor.author | Goggins, Bridie J | en |
dc.contributor.author | Tay, Hock | en |
dc.contributor.author | Mathe, Andrea | en |
dc.contributor.author | Soh, Wai S | en |
dc.contributor.author | Minahan, Kyra | en |
dc.contributor.author | Hansbro, Phil M | en |
dc.contributor.author | Nixon, Brett | en |
dc.contributor.author | McCaughan, Geoffrey W | en |
dc.contributor.author | Holtmann, Gerald | en |
dc.contributor.author | Colgan, Sean P | en |
dc.contributor.author | Keely, Simon | en |
dc.date.accessioned | 2023-06-26T02:06:42Z | - |
dc.date.available | 2023-06-26T02:06:42Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.uri | https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5248 | - |
dc.description.abstract | Liver inflammation is a common extraintestinal manifestation in inflammatory bowel disease (IBD), yet, the mechanisms driving gut-liver axis inflammation remain poorly understood. IBD leads to a breakdown in the integrity of the intestinal barrier causing an increase in portal and systemic gut-derived antigens, which challenge the liver. Here, we examined the role of platelet activating factor receptor (PAFR) in colitis-associated liver damage using dextran sulfate sodium (DSS) and anti-CD40-induced colitis models. Both DSS and anti-CD40 models exhibited liver inflammation associated with colitis. Colitis reduced global PAFR protein expression in mouse livers causing an exclusive re-localization of PAFR to the portal triad. The global decrease in liver PAFR was associated with increased sirtuin 1 while relocalized PAFR expression was limited to Kupffer cells (KCs) and co-localized with toll-like receptor 4. DSS activated the NLRP3-inflammasome and increased interleukin (IL)-1β in the liver. Antagonism of PAFR amplified the inflammasome response by increasing NLRP3, caspase-1, and IL-1β protein levels in the liver. LPS also increased NLRP3 response in human hepatocytes, however, overexpression of PAFR restored the levels of NLPR3 and caspase-1 proteins. Interestingly, KCs depletion also increased IL-1β protein in mouse liver after DSS challenge. These data suggest a protective role for PAFR-expressing KCs during colitis and that regulation of PAFR is important for gut-liver axis homeostasis. | en |
dc.language.iso | en | en |
dc.relation.ispartof | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | en |
dc.title | Platelet activating factor receptor acts to limit colitis-induced liver inflammation | en |
dc.type | Article | en |
dc.identifier.doi | 10.1096/fj.201901779R | - |
dc.identifier.pmid | 32293760 | - |
dc.rights.holder | Holtmann, Gerald | en |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
Appears in Sites: | Gastroenterology and Hepatology, Princess Alexandra Hospital |
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