Correlation Between Point-of-Care and Laboratory-Analyzed B-Type Natriuretic Peptide in Adult Patients Presenting to Nambour Hospital Emergency Department With Shortness of Breath

Abstract

International studies have demonstrated improved patient outcomes and cost benefits using B-type natriuretic peptide (BNP) testing (laboratory and point-of-care [POC]) for patients with acute dyspnea. There are no published studies validating the Abbott BNP POC test in the Australian setting. This study aims to validate the Abbott BNP POC test against the laboratory criterion standard (Beckman Coulter 2-site immunoenzymatic assay). During this study, blood BNP levels were measured using the Abbott POC analyzer and the laboratory. One-hundred fifty consecutive adult patients presenting with acute dyspnea to Nambour Hospital Emergency Department were recruited. B-type natriuretic peptide levels were compared, as were grouped levels using clinically useful accepted reference ranges (<100, 100-500, and >500 pg/mL). The data were tested using general correlation and least squares regression. The correlation between the POC and laboratory BNP results was strong, R2 = 0.87. There is a good correlation for the measurement of BNP between Abbott POC BNP and laboratory BNP analyzer. The Abbott (Chicago, Ill) POC BNP analyzer is suitable for measurement of BNP in Australian emergency departments.research; tables/charts. Journal Subset: Allied Health; Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Online/Print; Peer Reviewed; USA. Special Interest: Emergency Care. No. of Refs: 7 ref. NLM UID: 101165285. <br />