Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/6558
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dc.contributor.authorBurns, Grace Len
dc.contributor.authorPotter, Michaelen
dc.contributor.authorMathe, Andreaen
dc.contributor.authorBruce, Jessicaen
dc.contributor.authorMinahan, Kyraen
dc.contributor.authorBarnes, Jessica Len
dc.contributor.authorPryor, Jenniferen
dc.contributor.authorNieva, Cheenieen
dc.contributor.authorSherwin, Simonneen
dc.contributor.authorCuskelly, Annalisaen
dc.contributor.authorFairlie, Thomasen
dc.contributor.authorCameron, Raquelen
dc.contributor.authorBollipo, Stevenen
dc.contributor.authorIrani, Mudar Zanden
dc.contributor.authorFoster, Roberten
dc.contributor.authorGan, Lay Ten
dc.contributor.authorShah, Ayeshaen
dc.contributor.authorKoloski, Natashaen
dc.contributor.authorFoster, Paul Sen
dc.contributor.authorHorvat, Jay Cen
dc.contributor.authorWalker, Marjorie Men
dc.contributor.authorPowell, Nicken
dc.contributor.authorVeysey, Martinen
dc.contributor.authorDuncanson, Kerithen
dc.contributor.authorHoltmann, Geralden
dc.contributor.authorTalley, Nicholas Jen
dc.contributor.authorKeely, Simonen
dc.date.accessioned2024-12-11T02:21:35Z-
dc.date.available2024-12-11T02:21:35Z-
dc.date.issued2023-12-01-
dc.identifier.citationClinical and translational gastroenterology, 2023en
dc.identifier.urihttps://dora.health.qld.gov.au/qldresearchjspui/handle/1/6558-
dc.description.abstractAn association between functional dyspepsia (FD) and wheat-containing foods has been reported in observational studies; however, an adaptive response has not been demonstrated. We examined whether antigens present in wheat could provoke a response from FD duodenal lymphocytes. Lamina propria mononuclear cells (LPMCs) were isolated from duodenal biopsies from 50 patients with FD and 23 controls. LPMCs were exposed to gluten (0.2 mg/mL) or gliadin (0.2 mg/mL) for 24 hours. Flow cytometry was performed to phenotype lymphocytes. Quantitative PCR was used to measure the expression of gliadin-associated T-cell receptor alpha variant ( TRAV ) 26-2. In response to gliadin (but not gluten) stimulation, the effector Th2-like population was increased in FD LPMCs compared with that in controls and unstimulated FD LPMCs. Duodenal gene expression of TRAV26- 2 was decreased in patients with FD compared with that in controls. We identified a positive association between gene expression of this T-cell receptor variant and LPMC effector Th17-like cell populations in patients with FD, but not controls after exposure to gluten, but not gliadin. Our findings suggest that gliadin exposure provokes a duodenal effector Th2-like response in patients with FD, supporting the notion that food antigens drive responses in some patients. Furthermore, these findings suggest that altered lymphocyte responses to wheat proteins play a role in FD pathogenesis.en
dc.language.isoenen
dc.relation.ispartofClinical and Translational Gastroenterologyen
dc.titleTRAV26-2 T-Cell Receptor Expression Is Associated With Mucosal Lymphocyte Response to Wheat Proteins in Patients With Functional Dyspepsiaen
dc.identifier.doi10.14309/ctg.0000000000000638-
dc.identifier.pmid37753952-
dc.rights.holderHoltmann, Geralden
dc.identifier.journaltitleClinical and translational gastroenterology-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
Appears in Sites:Gastroenterology and Hepatology, Princess Alexandra Hospital
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